Human brain cells alive in mouse brains.

[This Truth from Error post first appeared in Scientific American, May 9, 2013.  Link:  http://bit.ly/ZM3CTT]

Into brains of newborn mice, researchers implanted human “progenitor cells.”  These mature into a type of brain cell called astrocytes (see below).  They grew into human astrocytes, crowding out mouse astrocytes.  The mouse brains became chimeras of human and mouse, with the workhorse mouse brain cells – neurons – nurtured by billions of human astrocytes.  Continue reading

An antibiotic that resistant microbes can’t defeat.

The dreaded methicillin-resistant bacteria that increasingly imperil hospital patients, do not defeat it.   Nor can tuberculosis bacteria.

This antibiotic is not new.  It is in fact natural, and probably a few thousand years old.  Nor is it rare:  it’s found in human sweat.  What is new is that researchers have revealed the structure of this undefeated weapon, and also how it kills a bacterium in one ten-thousandth of a second.  Continue reading

Astonishing consequence of 100 trillion microbes inhabiting healthy guts.

Maybe it’s not surprising that digestion and nutrient metabolism is affected by a human’s 100 trillion gut microbes.

But that physical development of a mammal’s body is altered by changes in gut microbes, this is astonishing.

Just discovered:  at puberty, gut microbe populations shift in male and female animals.  Before puberty, they’re similar.  Gut microbe shifts appear to drive male/female differences in post-puberty sex hormone production.  Continue reading

Eyes’ intricate mechanics: another ray of light

Vision, being familiar, can seem ordinary.  Animals of all sorts do it.  How remarkable can something universal be?

But shake off sleepy familiarity and amazement re-awakes.  What, exactly, happens in a retina cell when it absorbs a photon of light?  How, from a fertilized egg, do 100 million retina cells acquire a structure that sends electrical flickers to the brain?  Continue reading

That “junk” DNA: Life gets even more complicated.

Discovery of DNA’s helix structure in 1953 stoked enthusiasm that life’s secret would be soon revealed. The secret would be a chemical one, for complementarity of DNA’s four bases (in the helix ladder’s rungs) suggested a “code” in the molecule. Perhaps it’s like the Morse code, Francis Crick suggested to Sydney Brenner, where two “letters” – dot and dash – translate all written language. Might DNA’s four bases – A, G, C, T — translate all molecules active in life?

It turned out to be more complicated. Continue reading

Another mystery of heredity dispelled.

Nearly 60 years have passed since the Crick-Watson discovery of DNA’s helix structure.  “It has not escaped our notice,” they declared in the short Nature article announcing the breakthrough, that the structure implied an elegant mechanism of heredity. DNA replicates itself – that’s the mechanism – but with such complexity that many of its deeds remain concealed despite decades of research.

A couple of them are a little clearer, today.  Continue reading

How do descendants become different from ancestors?

This puzzled Darwin.  His answer was tiny changes accumulating over countless generations.  Descendants eventually become different species.  His finches on the Galapagos Islands made this plausible.  But what about new species in lakes?  Like in East Africa’s great lakes, but not in America’s Great Lakes.  DNA research today hints at answers, and mysteries still abound.  Continue reading

Electrical ripples erupting in a neuron for The Simpson’s.

Think of your memories as fastened on the dark interior of a vast, lofty dome.  “Searchlight of attention” is neuroscience’s metaphor for the power that illuminates one memory while leaving others in darkness.

No “ghost” in the brain aims the searchlight.  What else could?  Does your free will select one memory and thereby trigger chemical and electrical eruptions to make a neuron “fire”?  Does the immaterial mind, that is, fire up the physical brain? Continue reading